MEMES: Against Table 2 in the “Choosing Wisely Canada” T3 & T4 toolkit

The "Choosing Wisely Canada" toolkit promoting limitation of Free T3 and Free T4 testing has been the food for some meme refutations. Choosing Wisely Canada. (n.d.). Toolkit: Less is More with T3 & T4. Retrieved December 30, 2018, from https://choosingwiselycanada.org/perspective/toolkit-t4-t3/ Recently, we've focused on their Table 2 which outlines situations they recommend NOT to order … Continue reading MEMES: Against Table 2 in the “Choosing Wisely Canada” T3 & T4 toolkit

Ubiquitination: The glass ceiling of T4 monotherapy

UBIQUITINATION: This is the "Glass ceiling" of T4 monotherapy -- in some patients, there is a biological limit on how much T3 they can get out of treatment with T4 thyroid hormone alone (Synthroid, levothyroxine). Scientists recently explained how D2's gene (DIO3) is inactivated by rising levels of T4: "Although DIO2 expression is only weakly … Continue reading Ubiquitination: The glass ceiling of T4 monotherapy