Why are some people extremely hypothyroid while their TSH is above reference range, while others have no symptoms and are completely healthy? How important is the Free T3 test when diagnosing true "euthyroid" status within the TSH reference range? Is it true that a normal TSH alone, or a normal TSH and normal FT4 test … Continue reading Relational Stability, part 3: Shifting TSH-T4-T3 relationships
Does the statistically-defined "normal" TSH reference range for the healthy population describe the TSH range for a healthy individual? Does having a TSH within the normal laboratory range always mean you, as an individual are biologically euthyroid? Does falling outside statistical TSH normality really mean that you are hypothyroid or thyrotoxic? This is part 2 … Continue reading Relational Stability, Part 2: Normality of TSH and thyroid hormones
In a series of posts, I'm sharing my plainer-English paraphrase of a very important article in thyroid science. My hope is that the public, doctors, and educated thyroid patients can better understand and appreciate its insights. This article by Dr. Rudolf Hoermann and colleagues Midgley, Larisch, and Dietrich explains the complex interrelationships between TSH, T4 … Continue reading Relational stability among thyroid hormones and TSH, part 1
This is part 2 of a post which began with the question "How do we get enough T3 into our thyroid hormone receptors?" In this post, I discuss the factors that can prevent T3 from getting into receptors. There are two factors that usually operate together: 1) the "variable rate" of T4 conversion in cells, … Continue reading What can prevent T3 from getting into thyroid receptors?
In thyroid disease and therapy, even when TSH is normalized, we can still be genuinely hypothyroid if we do not have enough T3 getting into our thyroid hormone receptors in cells throughout the body. Most people know there's two ways we get T3 into our cells' nuclei: From circulating Free T3, andFrom circulating Free T4 … Continue reading How do we get enough T3 into thyroid hormone receptors?