Ingbar and Braverman’s historic study of LT4 monotherapy

As part of my post on “The thyroid gland is a T3 shield,” I reviewed a research article by Ingbar and team from 1982. Wow. What a treasure. The title of this article is “Elevated serum thyroxine concentration in patients receiving ‘replacement’ doses of levothyroxine.” Just look at that title. They began their title with the shocking word “elevated,” not the word “euthyroid,” “normalized” or “normalizing.” They dared to put the word “replacement” in quotation marks in the title, admitting a healthy doubt that a living gland that flexibly secretes two hormones can be fully replaced by static doses of …

Continue Reading