One of Thyroid Patients Canada's values is to bring to light little-known aspects of the history of thyroid therapy so that it can open minds about future possibilities. The history of L-T3 (Liothyronine) monotherapy brings to light the flexibility and diversity of our thyroid pharmaceuticals to adapt to the unique metabolic needs of the individual. … Continue reading Finkler, 1959: Liothyronine as a replacement for thyroid therapy
As part of my post on "The thyroid gland is a T3 shield," I reviewed a research article by Ingbar and team from 1982. Wow. What a treasure. The title of this article is "Elevated serum thyroxine concentration in patients receiving 'replacement' doses of levothyroxine." Just look at that title. They began their title with … Continue reading Ingbar and Braverman’s historic study of LT4 monotherapy
In 2011, Gullo's research team published a landmark study in thyroid therapy titled "Levothyroxine Monotherapy Cannot Guarantee Euthyroidism in All Athyreotic Patients." Gullo and colleagues examined the TSH, FT3 and FT4 levels and the FT3:FT4 ratios of 1,811 thyroidless patients on levothyroxine (LT4) monotherapy and compared them with 3,875 healthy controls. Gullo's study shook the … Continue reading Gullo: LT4 monotherapy and thyroid loss invert FT3 and FT4 per unit of TSH
They say that history is written by the victors. Not always. Sometimes histories are written by advocates for the oppressed and disenfranchised. A common theme on our website is the need to see current practices and thyroid therapy challenges in light of thyroid therapy history. Instead of trusting histories written by scientists, one ought to … Continue reading Mimicry: The idol of T3-T4 combo therapy 2004-2014
A trend in thyroid therapy, sparked by a 1995 rat study, attempted to mimic a narrowly estimated T3:T4 ratio secreted by human thyroid glands. This trend was based on a theory of pharmaceutical mimicry of "the" thyroid gland. Its proponents chose to represent every human being's thyroid gland by the narrow statistical average secretion ratio … Continue reading The foundations of synthetic T3-T4 therapy in the 1990s
