Principles & Practical tips for Reverse T3, FT3, FT4

This post follows up on several recent posts on the topic of Reverse T3 (RT3) and our thyroid hormone conversion enzymes, the three deiodinases. Here I'm providing some practical tips about Reverse T3 testing, test interpretation, and where we should be focusing our attention. In these posts, I aim to improve thyroid therapy by debunking …

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RT3 inhibits T4-T3 conversion. How worried should we be?

Many thyroid patients have learned to fear Reverse T3 (RT3) by reading Kent Holtorf's web pages. Likely even more have learned by reading Reverse T3 information on the Stop the Thyroid Madness (STTM) thyroid patients' website, which has been influenced by Holtorf, whom they cite. On the positive side, both of these websites share a …

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Deiodinase Type 3 plays the T3-blocking role

This is part 2 of a 2-part post (It was long, so I've decided to break it into two parts). Images & principles were shared in yesterday's post: Visualizing thyroid hormone activity in cells: T3 and RT3 in context Here's the corrected & clarified image that I developed based on Bianco et al, 2019's model: …

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Visualizing thyroid hormone activity in cells: T3 and RT3 in context

I've recently been inspired by an visual of thyroid hormone cellular action published by Bianco and colleagues in September, 2019. This visual has taught me a new way of seeing these hormones' pathways of movement and activity in our bodies. I've read Bianco's article quite thoroughly in light of the image, and as a result …

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The basics of thyroid hormone action, transport and conversion

This comprehensive educational post collects the basics of thyroid hormone, transport and conversion. T3 action on nuclear receptors Every organ and tissue in your body must maintain a healthy level of T3 hormone activity to function properly. Bloodstream T3 supply and local T3 action powerfully influences how every organ operates, from our liver to our …

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How thyroid guidelines are being used to punish doctors

Clinical guidelines are supposed to promote patient health and encourage evidence-based medicine and physician discernment, but thyroid guidelines aim to restrict testing, restrict medication, and prevent any change in therapy practices. Indeed, the enforcement of restrictions appears to be the main purpose of local and international thyroid therapy guidelines today. These thyroid therapy guidelines, and …

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2012 ATA thyroid guidelines ask for clinicians’ independent judgment

In recent years, Canadian and other international thyroid guidelines have enacted local policies that restrict thyroid therapy and testing, often citing the American Thyroid Association (ATA) & American Association of Clinical Endocrinologists' (AACE) guidelines in 2012. What most "guideline policers" fail to notice is that the 2012 ATA-AACE's guidelines begin with a disclaimer against their …

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