References for Thyrotoxicosis vs. Low TSH series

Posts in this series

July 2019

• Thyrotoxicosis? Many factors can lower TSH
• Thyrotoxicosis: Symptoms and signs
• Thyrotoxicosis vs. Low TSH
• Thyrotoxicosis can occur with high or normal TSH?
• TSH “can be very misleading” during thyroid therapy, say researchers
• How TSH ultrashort feedback works, and antibody interference
• Pregnancy thyrotoxicosis vs just a low TSH due to HCG hormone

REFERENCES

Anderson, J. L., Jacobs, V., May, H. T., Bair, T. L., Lappé, D. L., Muhlestein, J. B., … Bunch, T. J. (2018). Abstract 11290: Free Thyroxine (fT4) Within the Reference (‘Normal’) Range Predicts Risk of Atrial Fibrillation. Circulation, 138(Suppl_1), A11290–A11290. https://doi.org/10.1161/circ.138.suppl_1.11290

Bargi-Souza, P., Goulart-Silva, F., & Nunes, M. T. (2017). Novel aspects of T3 actions on GH and TSH synthesis and secretion: physiological implications. Journal of Molecular Endocrinology, 59(4), R167–R178. https://doi.org/10.1530/JME-17-0068

Baumgartner, C., da Costa, B. R., Collet, T.-H., Feller, M., Floriani, C., Bauer, D. C., … Thyroid Studies Collaboration. (2017). Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation. Circulation, 136(22), 2100–2116. https://doi.org/10.1161/CIRCULATIONAHA.117.028753

Beck-Peccoz, P., Rodari, G., Giavoli, C., & Lania, A. (2017). Central hypothyroidism – a neglected thyroid disorder. Nature Reviews. Endocrinology, 13(10), 588–598. https://doi.org/10.1038/nrendo.2017.47

Benvenga, S., Klose, M., Vita, R., & Feldt-Rasmussen, U. (2018). Less known aspects of central hypothyroidism: Part 1 – Acquired etiologies. Journal of Clinical & Translational Endocrinology, 14, 25–33. https://doi.org/10.1016/j.jcte.2018.09.003

Braverman, L. E., & Cooper, D. S. (2013). Introduction to thyrotoxicosis. In L. E. Braverman & D. S. Cooper (Eds.), Werner & Ingbar’s the thyroid: a fundamental and clinical text (10th ed..). Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health.

Braverman, L. E., & Utiger, R. D. (2000). Introduction to thyrotoxicosis. In L. E. Braverman & R. D. Utiger (Eds.), Werner & Ingbar’s the thyroid: a fundamental and clinical text. (8th ed., pp. 515–517). Philadelphia, PA: Lippincott Williams & Wilkins.

Brokken, J. S., Wiersinga, M., & Prummel, F. (2003). Thyrotropin Receptor Autoantibodies Are Associated with Continued Thyrotropin Suppression in Treated Euthyroid Graves’ Disease Patients. The Journal of Clinical Endocrinology & Metabolism, 88(9), 4135–4138. https://doi.org/10.1210/jc.2003-030430

Brokken, L. J., Scheenhart, J. W., Wiersinga, W. M., & Prummel, M. F. (2001). Suppression of serum TSH by Graves’ Ig: Evidence for a functional pituitary TSH receptor. The Journal of Clinical Endocrinology and Metabolism, 86(10), 4814–4817. https://doi.org/10.1210/jcem.86.10.7922

Charalambous, M., & Hernandez, A. (2013). Genomic imprinting of the type 3 thyroid hormone deiodinase gene: Regulation and developmental implications. Biochimica et Biophysica Acta, 1830(7), 3946–3955. https://doi.org/10.1016/j.bbagen.2012.03.015

Christy, J. H., & Morse, R. S. (1977). Hypothyroid Graves’ disease. The American Journal of Medicine, 62(2), 291–296. https://doi.org/10.1016/0002-9343(77)90325-4

Cole, L. A., Khanlian, S. A., & Muller, C. Y. (2009). Normal production of human chorionic gonadotropin in perimenopausal and menopausal women and after oophorectomy. International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society, 19(9), 1556–1559.

Diana, T., Wüster, C., Kanitz, M., & Kahaly, G. J. (2016). Highly variable sensitivity of five binding and two bio-assays for TSH-receptor antibodies. Journal of Endocrinological Investigation, 39(10), 1159–1165. https://doi.org/10.1007/s40618-016-0478-9

DIETRICH, J. W., TESCHE, A., PICKARDT, C. R., & MITZDORF, U. (2004). Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis. Cybernetics and Systems, 35(4), 315–331. https://doi.org/10.1080/01969720490443354

Dumitrescu, A. M., & Refetoff, S. (2013). The syndromes of reduced sensitivity to thyroid hormone. Biochimica et Biophysica Acta, 1830(7), 3987–4003. https://doi.org/10.1016/j.bbagen.2012.08.005

Egri, P., Fekete, C., Dénes, Á., Reglődi, D., Hashimoto, H., Fülöp, B. D., & Gereben, B. (2016). Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Regulates the Hypothalamo-Pituitary-Thyroid (HPT) Axis via Type 2 Deiodinase in Male Mice. Endocrinology, 157(6), 2356–2366. https://doi.org/10.1210/en.2016-1043

Evans, M., Sanders, J., Tagami, T., Sanders, P., Young, S., Roberts, E., … Smith, B. R. (2010). Monoclonal autoantibodies to the TSH receptor, one with stimulating activity and one with blocking activity, obtained from the same blood sample. Clinical Endocrinology, 73(3), 404–412. https://doi.org/10.1111/j.1365-2265.2010.03831.x

Fliers, E., Kalsbeek, A., & Boelen, A. (2014). Beyond the fixed setpoint of the hypothalamus-pituitary-thyroid axis. European Journal of Endocrinology, 171(5), R197-208. https://doi.org/10.1530/EJE-14-0285

Fliers, E., Wiersinga, W. M., & Swaab, D. F. (1998). Physiological and pathophysiological aspects of thyrotropin-releasing hormone gene expression in the human hypothalamus. Thyroid: Official Journal of the American Thyroid Association, 8(10), 921–928. https://doi.org/10.1089/thy.1998.8.921

Flier, J. S., Harris, M., & Hollenberg, A. N. (2000). Leptin, nutrition, and the thyroid: The why, the wherefore, and the wiring. Journal of Clinical Investigation, 105(7), 859–861. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC377492/

Fröhlich, E., & Wahl, R. (2017). Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases. Frontiers in Immunology, 8. https://doi.org/10.3389/fimmu.2017.00521

Gałecka, E., Kumor-Kisielewska, A., Orzechowska, A., Maes, M., Górski, P., & Szemraj, J. (2017). Assessment of type 1 and type 3 deiodinase expression levels in depressive disorders. Acta Neurobiologiae Experimentalis, 77(3), 225–235.

Gelwane, G., de Roux, N., Chevenne, D., Carel, J. C., & Léger, J. (2009). Pituitary-thyroid feedback in a patient with a sporadic activating thyrotropin (TSH) receptor mutation: Implication that thyroid-secreted factors other than thyroid hormones contribute to serum TSH levels. The Journal of Clinical Endocrinology and Metabolism, 94(8), 2787–2791. https://doi.org/10.1210/jc.2008-2524

Hoftijzer, C., Heemstra, A., Visser, J., Le Cessie, P., Peeters, M., Corssmit, A., & Smit, A. (2011). The Type 2 Deiodinase ORFa-Gly3Asp Polymorphism (rs12885300) Influences the Set Point of the Hypothalamus-Pituitary-Thyroid Axis in Patients Treated for Differentiated Thyroid Carcinoma. The Journal of Clinical Endocrinology & Metabolism, 96(9), E1527–E1533. https://doi.org/10.1210/jc.2011-0235

Jonklaas, J., & Burman, K. D. (2016). Daily Administration of Short-Acting Liothyronine Is Associated with Significant Triiodothyronine Excursions and Fails to Alter Thyroid-Responsive Parameters. Thyroid, 26(6), 770–778. https://doi.org/10.1089/thy.2015.0629

Jonklaas, J., Burman, K. D., Wang, H., & Latham, K. R. (2015). Single Dose T3 Administration: Kinetics and Effects on Biochemical and Physiologic Parameters. Therapeutic Drug Monitoring, 37(1), 110–118. https://doi.org/10.1097/FTD.0000000000000113

Jostel, A., Ryder, W. D. J., & Shalet, S. M. (2009). The use of thyroid function tests in the diagnosis of hypopituitarism: Definition and evaluation of the TSH Index. Clinical Endocrinology, 71(4), 529–534. https://doi.org/10.1111/j.1365-2265.2009.03534.x

Kahaly, G. J., & Diana, T. (2017). TSH Receptor Antibody Functionality and Nomenclature. Frontiers in Endocrinology, 8. https://doi.org/10.3389/fendo.2017.00028

Kakita, T., Laborde, N. P., & Odell, W. D. (1984). Autoregulatory control of thyrotropin in rabbits. Endocrinology, 114(6), 2301–2305. https://doi.org/10.1210/endo-114-6-2301

Kakita, T., & Odell, W. D. (1986). Pituitary gland: One site of ultrashort-feedback regulation for control of thyrotropin. The American Journal of Physiology, 250(2 Pt 1), E121-124. https://doi.org/10.1152/ajpendo.1986.250.2.E121

Kalra, S., Khandelwal, S. K., & Goyal, A. (2011). Clinical scoring scales in thyroidology: A compendium. Indian Journal of Endocrinology and Metabolism, 15(Suppl2), S89–S94. https://doi.org/10.4103/2230-8210.83332

Kannan, L., Shaw, P. A., Morley, M. P., Brandimarto, J., Fang, J. C., Sweitzer, N. K., … Cappola, A. R. (2018). Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes. Circulation. Heart Failure, 11(12), e005266. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005266

Kluge, M., Schmidt, D., Uhr, M., & Steiger, A. (2013). Ghrelin suppresses nocturnal secretion of luteinizing hormone (LH) and thyroid stimulating hormone (TSH) in patients with major depression. Journal of Psychiatric Research, 47(9), 1236–1239. https://doi.org/10.1016/j.jpsychires.2013.05.010

Krassas, G. E., Pontikides, N., Kaltsas, T., Papadopoulou, P., & Batrinos, M. (1994). Menstrual disturbances in thyrotoxicosis. Clinical Endocrinology, 40(5), 641–644.

Krassas, G. E., Pontikides, N., Kaltsas, T., Papadopoulou, P., Paunkovic, J., Paunkovic, N., & Duntas, L. H. (1999). Disturbances of menstruation in hypothyroidism. Clinical Endocrinology, 50(5), 655–659.

Labrie, F., Drouin, J., Ferland, L., Lagacé, L., Beaulieu, M., De léan, A., … Raymond, V. (1978). Mechanism of Action of Hypothalamic Hormones in the Anterior Pituitary Gland and Specific Modulation of Their Activity by Sex Steroids and Thyroid Hormones. In R. O. Greep (Ed.), Proceedings of the 1977 Laurentian Hormone Conference (pp. 25–93). https://doi.org/10.1016/B978-0-12-571134-0.50006-5

Ladenson, P. W., Goldenheim, P. D., & Ridgway, E. C. (1983). Rapid pituitary and peripheral tissue responses to intravenous L-triiodothyronine in hypothyroidism. The Journal of Clinical Endocrinology and Metabolism, 56(6), 1252–1259. https://doi.org/10.1210/jcem-56-6-1252

Lesho, E., & Jones, R. E. (1997). Hypothyroid Graves’ disease. Southern Medical Journal, 90(12), 1201–1203. https://doi.org/10.1097/00007611-199712000-00007

Morshed, S. A., & Davies, T. F. (2015). Graves’ Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme, 47(10), 727–734. https://doi.org/10.1055/s-0035-1559633

Refetoff, S., Bassett, J. H. D., Beck-Peccoz, P., Bernal, J., Brent, G., Chatterjee, K., … Yen, P. M. (2014). Classification and Proposed Nomenclature for Inherited Defects of Thyroid Hormone Action, Cell Transport, and Metabolism. Thyroid, 24(3), 47–409. https://doi.org/10.1089/thy.2013.3393.nomen

Russell, W., Harrison, R. F., Smith, N., Darzy, K., Shalet, S., Weetman, A. P., & Ross, R. J. (2008). Free Triiodothyronine Has a Distinct Circadian Rhythm That Is Delayed but Parallels Thyrotropin Levels. The Journal of Clinical Endocrinology & Metabolism, 93(6), 2300–2306. https://doi.org/10.1210/jc.2007-2674

Samuels, M. H. (2000). Effects of variations in physiological cortisol levels on thyrotropin secretion in subjects with adrenal insufficiency: A clinical research center study. The Journal of Clinical Endocrinology and Metabolism, 85(4), 1388–1393. https://doi.org/10.1210/jcem.85.4.6540

Schwartz, K. M., Fatourechi, V., Ahmed, D. D. F., & Pond, G. R. (2002). Dermopathy of Graves’ Disease (Pretibial Myxedema): Long-Term Outcome. The Journal of Clinical Endocrinology & Metabolism, 87(2), 438–446. https://doi.org/10.1210/jcem.87.2.8220

Scoccia, B., Bernardi, L. A., Alvarez, J. P., Fierro, M. A., & Winston, N. J. (2013). Significant TSH changes induced by estrogen and progesterone administration in hypothyroid patients undergoing preparation for frozen embryo transfer. Fertility and Sterility, 100(3), S475. https://doi.org/10.1016/j.fertnstert.2013.07.462

Sharma, V., Hays, W. R., Wood, W. M., Pugazhenthi, U., Germain, S., L, D., … Haugen, B. R. (2006). Effects of Rexinoids on Thyrotrope Function and the Hypothalamic-Pituitary-Thyroid Axis. Endocrinology, 147(3), 1438–1451. https://doi.org/10.1210/en.2005-0706

Tabasum, A., Khan, I., Taylor, P., Das, G., & Okosieme, O. E. (2016). Thyroid antibody-negative euthyroid Graves’ ophthalmopathy. Endocrinology, Diabetes & Metabolism Case Reports, 2016. https://doi.org/10.1530/EDM-16-0008

Takasu, N., Yamada, T., Takasu, M., & Komiya, I. (1992). Disappearance of thyrotropin-blocking antibodies and spontaneous recovery from hypothyroidism in autoimmune thyroiditis. The New England Journal of Medicine, 326(8), 513. https://doi.org/10.1056/NEJM199202203260803

Takasu, N., & Matsushita, M. (2012). Changes of TSH-Stimulation Blocking Antibody (TSBAb) and Thyroid Stimulating Antibody (TSAb) Over 10 Years in 34 TSBAb-Positive Patients with Hypothyroidism and in 98 TSAb-Positive Graves’ Patients with Hyperthyroidism: Reevaluation of TSBAb and TSAb in TSH-Receptor-Antibody (TRAb)-Positive Patients. Journal of Thyroid Research, 2012, 182176. https://doi.org/10.1155/2012/182176

von Hafe, M., Neves, J. S., Vale, C., Borges-Canha, M., & Leite-Moreira, A. (2019). The impact of thyroid hormone dysfunction on ischemic heart disease. Endocrine Connections. https://doi.org/10.1530/EC-19-0096

Wu, D., Guo, R., Guo, H., Li, Y., Guan, H., & Shan, Z. (2018). Resistance to thyroid hormone β in autoimmune thyroid disease: A case report and review of literature. BMC Pregnancy and Childbirth, 18(1), 468. https://doi.org/10.1186/s12884-018-2110-9

Yu, H., & Farahani, P. (2014). TSH Suppression Post-Therapy in Graves’ Disease: A Systematic Review on Pathophysiology and Clinical Data. Canadian Journal of Diabetes, 38(5, Supplement), S4. https://doi.org/10.1016/j.jcjd.2014.07.010

Zhang, Z., Boelen, A., Bisschop, P. H., Kalsbeek, A., & Fliers, E. (2017). Hypothalamic effects of thyroid hormone. Molecular and Cellular Endocrinology, 458, 143–148. https://doi.org/10.1016/j.mce.2017.01.018