Thyroid Testing
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23 years of misdiagnosed central hypothyroidism with a normal TSH: Case study

In this post, I’ll comment on the case study of a woman who suffered for 23 years with undiagnosed central hypothyroidism between 1992 and 2015 (age 34 to age 57) because her TSH was repeatedly in normal range. She developed impaired kidney function, muscle damage, and pericardial effusion. Who saved the day? A biochemist working…
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Reverse T3 in the context of health status, dosages, and thyroid levels

A collection of research graphs and quotations showing diverse Reverse T3 levels coexisting with health, in various illnesses, and alongside various T3 and T4 levels.
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Gullo: LT4 monotherapy and thyroid loss invert FT3 and FT4 per unit of TSH

In 2011, Gullo’s research team published a landmark study in thyroid therapy titled “Levothyroxine Monotherapy Cannot Guarantee Euthyroidism in All Athyreotic Patients.” Gullo and colleagues examined the TSH, FT3 and FT4 levels and the FT3:FT4 ratios of 1,811 thyroidless patients on levothyroxine (LT4) monotherapy and compared them with 3,875 healthy controls. Gullo’s study shook the…
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Normal FT3:FT4 thyroid hormone ratios in large populations

A normal ratio of Free T3 (FT3) to Free T4 (FT4) thyroid hormones appears to be a basic principle in thyroid hormone economy when no thyroid hormone dosing and no disease interfere. In this post, I provide graphs, quotations, and discussions from Gullo, Strich, and Anderson as I present their FT3:FT4 ratio results, and I…
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The significance of the TSH-FT3 circadian rhythm

In my earlier post about circadian rhythms in thyroid health, I asked two quiz questions about TSH, FT3 and FT4 variability. First I asked “Which value varies the most during the day, a) TSH, b) Free T3 or c) Free T4?” There, I showed you, through various visuals by Russell et al, 2008, that TSH…
