How TSH ultrashort feedback works, and antibody interference

This post takes a closer look at the "ultrashort feedback loop," the biological mechanism by which the TSHR stimulating antibody (TSAb) can oversuppress TSH in any autoimmune hypothyroid patient. TSHR ANTIBODY EFFECTS ON MANY ORGANS As most people know, in Graves' disease, when TSH receptors on the thyroid gland are overstimulated by TSH-Receptor antibodies (TSAb), …

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TSH “can be very misleading” during thyroid therapy, say researchers

How many treated hypothyroid patients' TSH has fallen below range even when both their thyroid hormones are in normal range and when they have no symptoms or signs of hyperactivity or hypermetabolism? In my observation on thyroid patient forums, the answer is "too many." It's common among thyroid patients to resort to such forums for …

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Thyrotoxicosis? Many factors can lower TSH

Many substances and health factors can, independently of thyroid hormones, lower TSH secretion significantly. These factors are not listed in Braverman & Cooper's chapter on thyrotoxicosis in Werner & Ingbar's The Thyroid textbook, 10th edition 2013, because their chapter avoids defining the syndrome by a low TSH. Nevertheless, these TSH-lowering factors should always be mentioned …

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TSHR Antibodies can distort TSH secretion

There’s an underestimated, under-studied TSH feedback loop that almost nobody talks about. By means of acting on this feedback loop, a thyroid antibody may have a direct effect on TSH secretion as well as our T4 and T3 levels. This antibody is far more prevalent and clinically relevant than many endocrinologists and our health care …

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BIBLIO: Atrophic Thyroiditis

We have compiled a bibliography on Atrophic Thyroiditis and the TSHR antibody that is continually under development. 127 items exist in the bibliography as of December 2018 Screenshot The database is in a Google Spreadsheet. Click this link to access : https://docs.google.com/spreadsheets/d/1MlwMCGUnEF_ptUE9S9znMnN5oNkuAqA2fUNxvD2zrRw/edit?usp=sharing  

The THIRD type of autoimmune thyroid disease: Atrophic Thyroiditis

Do you know about the THIRD type of autoimmune thyroid disease? Atrophic Thyroiditis causes hypothyroidism, but it's NOT Hashimoto's. Myths and lack of knowledge Most doctors and patients have never heard about Atrophic Thyroiditis (AT). That's because it's not taught in med school, and an ultrasound is not usually ordered unless a thyroid gland is …

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REVIEW: Autoimmune thyroid disease in Coeliac patients

A 2018 research study recruited 341 coeliac [celiac] disease patients and found that 91 of them (26.6%) had at least one autoimmune disease. Among those 91 patients, 44 patients (48.4%) also had a diagnosis of autoimmune thyroid disease. These coeliac patients with autoimmune thyroid disease constituted 12.9% of the total sample of 341 coeliac patients. …

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