Low T3 syndrome in thyroid therapy: THREE studies

In contrast with a long list of over 70 medical research articles on low T3 syndrome that excluded thyroid patients, I have only found three (3) studies so far that included patients being treated for hypothyroidism. I'll reveal their treasures and disappointments in reverse date order: Somppi, 2017 Tevaarwerk, 2014 Wadwekar, 2004 Here's how many …

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Ataoglu: Low T3 in critical illness is deadly, and adding high T4 is worse.

In 2018, Ataoglu and colleagues confirmed and expanded our knowledge of "Low T3 syndrome." Despite a normalized TSH, a Low T3 is deadly not only in acute, critical illness, but in "chronic disease." To be specific, Low T3 is more deadly in some health conditions than others. What should be really shocking to many is …

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In Winter, everyone gains T3 except thyroidless patients on T4

A 2017 article reported research on 11,806 healthy controls and 3,934 thyroidless people treated with L-T4 monotherapy in Sicily, and then did a more in-depth "retrospective longitudinal" study on 119 of the thyroid patients compared to 156 matched controls. They discovered that the thyroid-disabled people lost a "significant" amount of Free T4 and Free T3 …

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The science of thyroid hormone and bone metabolism

This article is for people interested in getting an overview of the influence of thyroid hormones on bone health at the molecular level. It outlines the way bone transports, metabolizes, and uses thyroid hormones T3 and T4. It also raises theoretical implications for people with low T3 during TSH-suppressive T4 monotherapy. Here I draw mainly …

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As of 2019, still no proof that low TSH causes harm to bones

Many research studies have shown a strong association between low TSH and low bone mineral density or osteoporosis. As a result, many guidelines strongly caution against the risk associated with low TSH. Some doctors and thyroid patients have jumped to the conclusion that a low TSH “causes” osteoporosis. Some even believe a low TSH must …

Continue reading As of 2019, still no proof that low TSH causes harm to bones

2014 ATA therapy guidelines: 5. Research

This post continues my series of paraphrases of Jonklaas et al's 2014 guidelines that I left unfinished weeks ago. Here I provide paraphrases and quotations of what they set forth for the "ethics" of research in thyroid therapy in Section 18, and what they recommend as topics for future research in thyroid therapy. I provide …

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TSH “can be very misleading” during thyroid therapy, say researchers

How many treated hypothyroid patients' TSH has fallen below range even when both their thyroid hormones are in normal range and when they have no symptoms or signs of hyperactivity or hypermetabolism? In my observation on thyroid patient forums, the answer is "too many." It's common among thyroid patients to resort to such forums for …

Continue reading TSH “can be very misleading” during thyroid therapy, say researchers