The loss of thyroid clinical knowledge from Werner & Ingbar’s The Thyroid

Decades ago, a lot more doctors knew how thyroid hormone levels influenced all organs and tissues’ health. It wasn’t all about the influence of thyroid hormones on the TSH. It was more about the influence of truly adequate thyroid hormone levels on real health outcomes. A lot more doctors learned and understood that if thyroid …

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Question Pilo’s Study: Thyroid Hormone Reductionism

Many aspects of biology are incredibly complex. People love simplicity. It’s necessary for a model to reduce a system down to its basic principles and proportions. Pilo’s research study published in 1990 is now cited as the definitive proof of where human beings’ T3 thyroid hormone supply comes from. Pilo’s paper is what many people …

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Question Pilo’s study: The wide range of thyroid hormone adaptation

Doctors today are taught that “the” thyroid secretes T4 and T3 at a ratio of 14:1, or 15:1, and “the” human body converts 80% of its T3 supply from T4. These ratios are now taught and passed on as if they are static, immutable laws of nature, like the law of gravity. However, studies of complex …

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Question Pilo’s study: Iodine dosing biases T4:T3 secretion

This post continues my series that examines two ratios T4:T3 thyroid hormone secreted by “the” thyroid gland. The single origin of both these ratios is an article by Pilo et al published in 1990.    A simple summary: In Pilo's' study, the huge doses of iodine these 14 people were given every day during the …

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Question Pilo’s 1990 study. It can be misused to limit your T3 supply.

In this series, I am examining two T4-T3 thyroid hormone ratios that have been circulating in thyroid medical literature for decades. The first ratio is the “molar ratio” of T4 and T3 hormone secretion from the thyroid gland. The second ratio is the theory that the human body derives 20% of its T3 hormone supply from …

Continue reading Question Pilo’s 1990 study. It can be misused to limit your T3 supply.

The two T4-T3 ratios that confine thyroid therapy

Here are the two most pervasive, limiting, and potentially harmful presumptions about T3:T4 hormone ratios in thyroid science today.   Ratio #1: There is a perfect physiological T4:T3 ratio secreted from the healthy human thyroid gland, and it is approximately 15:1. (Various ratios are cited, most often from 13:1 to 16:1) Ratio #2: In the …

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Publications: John E. Midgley, thyroid scientist

Selected publications PARLIAMENTARY TESTIMONY (VIDEO) The Scottish Parliament. (2017). Public Petitions Committee - Scottish Parliament: 15 June 2017. Retrieved from https://www.youtube.com/watch?v=Tcx640AJuF8 AS SINGLE-AUTHOR AND LEAD AUTHOR Midgley, John E. M., Larisch, R., Dietrich, J. W., & Hoermann, R. (2015). Variation in the biochemical response to l-thyroxine therapy and relationship with peripheral thyroid hormone conversion efficiency. …

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