In this educational post, I introduce our thyroid hormone conversion enzyme “deiodinase type 1” (D1) in the personality of “The philanthropist” as I draw on many scientific articles. Of course, D1 is a genderless enzyme. I am personifying “her” in… Read More ›
Thyroid hormone conversion
The 7 lessons of the thyroid hormone deiodinases
The recent post “Thyroid hormone journey: Metabolism” is an educational compendium of diagrams, tables and bullet lists that highlight key lessons from the past five decades of thyroid science. It’s like a booklet in a blog post. The article concluded… Read More ›
Thyroid hormone journey: Metabolism
As one follows the thyroid hormone journey through the human body, at a crucial stage inside many of our cells, a beautiful and complex cascade transforms our thyroid hormones. Three deiodinase enzymes, types 1, 2 and 3 (D1, D2, D3),… Read More ›
Infographic: Thyroid hormone journey
This summary blog post will take you through a visual journey as you follow thyroid hormones through bloodstream, transporters, cells, and receptors. This infographic is not like most others you’ll see that portray a gland-centric view of the HPT axis…. Read More ›
Tissue RNA expression of DIO1, DIO2, and DIO3
No, this is not just an article for thyroid science buffs. Anyone who claims to understand thyroid hormone metabolism should become comfortable using the word “deiodinase.” It’s just as important a word for thyroid disease as “insulin” is for diabetes…. Read More ›
Principles and Practical tips for Reverse T3, FT3, FT4
This post follows up on several recent posts on the topic of Reverse T3 (RT3) and our thyroid hormone conversion enzymes, the three deiodinases. Here I’m providing some practical tips about Reverse T3 testing, test interpretation, and where we should… Read More ›
RT3 inhibits T4-T3 conversion. How worried should we be?
Many thyroid patients have learned to fear Reverse T3 (RT3) by reading Kent Holtorf’s web pages. Likely even more have learned by reading Reverse T3 information on the Stop the Thyroid Madness (STTM) thyroid patients’ website, which has been influenced… Read More ›
Deiodinase Type 3 plays the T3-blocking role
This is part 2 of a 2-part post (It was long, so I’ve decided to break it into two parts). Images & principles were shared in yesterday’s post: Visualizing thyroid hormone activity in cells: T3 and RT3 in context The… Read More ›