The science of thyroid hormone and bone metabolism

This article is for people interested in getting an overview of the influence of thyroid hormones on bone health at the molecular level. It outlines the way bone transports, metabolizes, and uses thyroid hormones T3 and T4. It also raises theoretical implications for people with low T3 during TSH-suppressive T4 monotherapy. Here I draw mainly …

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TSH “can be very misleading” during thyroid therapy, say researchers

How many treated hypothyroid patients' TSH has fallen below range even when both their thyroid hormones are in normal range and when they have no symptoms or signs of hyperactivity or hypermetabolism? In my observation on thyroid patient forums, the answer is "too many." It's common among thyroid patients to resort to such forums for …

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The impact of thyroid hormone dysfunction on ischemic heart disease, and how T3 therapy may help

Finally! In the past, the overemphasis on hyperthyroidism and thyrotoxicosis and heart diseases has made many doctors think that only excess T3 and T4 is bad for the heart. We finally have an article that focuses on the real cause-effect relationships on the opposite end of the thyroid dysfunction spectrum: HYPOthyroidism. This May 2019 article …

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Analyze thyroid lab results using SPINA-Thyr

This post walks through the process of using the SPINA-Thyr to interpret thyroid lab test results. OVERVIEW SPINA-Thyr is a free diagnostic application. SPINA-Thyr takes thyroid laboratory test values TSH, Free T4 and Free T3 and performs calculations that enable in-depth evaluation of thyroid function, pituitary function, and T4-T3 conversion for people who are on no …

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No, T4 does not always convert to enough T3.

"T4 is converted into T3 at the cellular level in virtually all organs" This is what Canada's endocrinologists claim at the opening of their statement under their recommendation "Don’t use Free T4 or T3 to screen for hypothyroidism or to monitor and adjust levothyroxine (T4) dose in patients with known primary hypothyroidism." What does this …

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Ubiquitination: The glass ceiling of T4 monotherapy

UBIQUITINATION: This is the "Glass ceiling" of T4 monotherapy -- there is a biological limit on how much T3 you can get out of treatment with T4 thyroid hormone alone (Synthroid, levothyroxine). The enzyme responsible for the majority of our body's T4-T3 conversion is Deiodinase Type 2 (D2), and it does its job of conversion …

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