Deiodinases
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Do you have a Reverse T3 problem?
Across Canada, Reverse T3 testing is often offered for a fee — patients usually pay for it. It has been this way for more than a few years now. As patients (and doctors), we need to know when we can save our money and avoid testing Reverse T3 by learning about its elevation indirectly. Here’s…
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How the three deiodinases regulate T3
Dear thyroid patients: If you’ve never heard about the deiodinases, your life and future health may depend on you learning about them. The deiodinases can either work with your thyroid meds or against them. It’s a lifelong condition, being on thyroid therapy, so there’s time for thyroid knowledge to sink in. I don’t have a bioscience…
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GRAPHIC and discussion: T3 Depletion
Illness as trigger of T3 depletion Science understands this process of T3 depletion as “non-thyroidal illness.” It has been called “non-thyroidal” because paradoxically, people with normal thyroid glands experience this deep, yet temporary hypothyroidism when they become very ill. It is believed that during illness, the body protects itself by lowering its metabolic set-point. The…
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REVIEW: DIO1 gene affects T3:T4 ratio
Panicker et al, 2008 Click title to read it online: A Common Variation in Deiodinase 1 Gene DIO1 Is Associated with the Relative Levels of Free Thyroxine and Triiodothyronine Background “D1 is found in liver, kidney, thyroid, and pituitary” and as blood flows through these organs, D1 converts T4 into T3, increasing levels of Free T3…
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GRAPHIC: Genes and thyroid hormones
Genetic polymorphisms in DIO1 and DIO2 and thyroid hormone transporters can influence your health even if you have a healthy thyroid gland. In thyroid patients, it can also affect the way you respond to thyroid hormone medication. L-T4 monotherapy reduces Free T3 and raises T4 in all patients, but patients with DIO1 and DIO2 genetic…