Category: Genetics

Thyrotoxicosis? Many factors can lower TSH

by thyroidpatientsca, posted in Central hypo, Diet & Nutrition, Genetics, Hypothalamus, Pituitary gland, Reference ranges, Research Reviews, Thyrotoxicosis, TSH hormone, TSHR-Antibody

Many substances and health factors can, independently of thyroid hormones, lower TSH secretion significantly. These factors are not listed in Braverman & Cooper's chapter on thyrotoxicosis in Werner & Ingbar's The Thyroid textbook, 10th edition 2013, because their chapter avoids defining the syndrome by a low TSH. Nevertheless, these TSH-lowering factors should always be mentioned … Continue reading Thyrotoxicosis? Many factors can lower TSH

Part 5: All thyroid meds are bioidentical, but individual response varies widely

by thyroidpatientsca, posted in Genetics, NDT / Desiccated thyroid, T3-T4 combo-therapy, T4-monotherapy, Thyroid pharma

This post concludes my response to a misleading video (10). THYROID HORMONE PHARMACEUTICALS A suspicion many people have is that thyroid hormone pharmaceuticals are very different from the thyroid hormones our bodies produce. Let's look into the claim that they are "bioidentical" in structure and function. Synthetic thyroid hormone has a counter-clockwise rotated molecule (it … Continue reading Part 5: All thyroid meds are bioidentical, but individual response varies widely

REVIEW: DIO1 gene affects T3:T4 ratio

by thyroidpatientsca, posted in Biomarkers, Deiodinases, FT3:FT4 ratio, Genetics, Research Reviews

Panicker et al, 2008 Click title to read it online: A Common Variation in Deiodinase 1 Gene DIO1 Is Associated with the Relative Levels of Free Thyroxine and Triiodothyronine Background "D1 is found in liver, kidney, thyroid, and pituitary" and as blood flows through these organs, D1 converts T4 into T3, increasing levels of Free T3 … Continue reading REVIEW: DIO1 gene affects T3:T4 ratio

GRAPHIC: Genes and thyroid hormones

by , posted in Deiodinases, Genetics

Genetic polymorphisms in DIO1 and DIO2 and thyroid hormone transporters can influence your health even if you have a healthy thyroid gland. In thyroid patients, it can also affect the way you respond to thyroid hormone medication.  L-T4 monotherapy reduces Free T3 and raises T4 in all patients, but patients with DIO1 and DIO2 genetic … Continue reading GRAPHIC: Genes and thyroid hormones