Renew the paradigm. Optimize our therapy.
What does NEW thyroid science have to say on the topic of thyroid pharmaceutical equivalency? How many micrograms of L-T3 Liothyronine (i.e. Cytomel) are equivalent to L-T4 Levothyroxine (i.e. Synthroid)? Thyroid hormone pharmaceutical monographs currently provide very rigid and low-ratio equivalency statements: ERFA Canada says "Desiccated thyroid 60 mg is usually considered equivalent to ... …
Continue reading L-T3 pharmaceutical equivalency, Part 2: New thyroid science
In thyroid therapy, how many micrograms of Cytomel (T3) are equivalent to how many micrograms of Synthroid (T4)? Equivalency statements in the product monographs for Pfizer Canada's Cytomel and for ERFA Canada's "Thyroid" (NDT brand) claim that a 25 mcg dose of Liothyronine sodium (L-T3) is "considered equivalent" to 100 mcg / μg (0.1 mg) …
Continue reading No, 25 mcg of L-T3 Liothyronine isn’t equivalent to 100 mcg L-T4
Here I bring thyroid science into a discussion of effectively adapting and managing the most flexible form of thyroid therapy, T4-T3 combination therapy. This is a model capable of adapting to an individual's unique thyroid disability and response to thyroid medication. Finding an individual's optimal combination therapy is medically necessary when T4 monotherapy fails due …
Continue reading Flexible-Ratio T3, T4, and NDT Combination Thyroid Therapy
I'd like to talk about contemporary researchers' rigid and limited approach to combination therapy. This is the model whose many limitations I point out with the ridiculously long label "mini-T3-mono-combination" therapy. I'll go over some of the history behind this model, the source of the rigid ratios that we learned about in our series on …
Continue reading The mini-T3-mono-combination therapy model vs NDT and others
In this series, I am examining two T4-T3 thyroid hormone ratios that have been circulating in thyroid medical literature for decades. The first ratio is the “molar ratio” of T4 and T3 hormone secretion from the thyroid gland. The second ratio is the theory that the human body derives 20% of its T3 hormone supply from …
Continue reading Question Pilo’s 1990 study. It can be misused to limit your T3 supply.
Here are the two most pervasive, limiting, and potentially harmful presumptions about T3:T4 hormone ratios in thyroid science today. Ratio #1: There is a perfect physiological T4:T3 ratio secreted from the healthy human thyroid gland, and it is approximately 15:1. (Various ratios are cited, most often from 13:1 to 16:1) Ratio #2: In the …
Continue reading The two T4-T3 ratios that confine thyroid therapy
This post continues my paraphrase of Jonklaas et al's 2014 "Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement." As I've explained in my previous post, I've decided not to let my summaries of ATA statements be an uninterrupted series of self-justifications and defenses. I've decided …
Continue reading 2014 ATA Therapy guidelines: 4. Using Synthetic T3
