T3-T4 combo-therapy
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Canadian LT3 brands: TEVA vs. Cytomel bioequivalence, fasted vs. fed
Did you know that Canadian TEVA LT3 has a much faster-release effect than Canadian Cytomel LT3 in the fasted state? They are not bioequivalent in all ways, despite Health Canada approval following a bioequivalence study. In addition, both Canadian brands have a “slower-release” effect when dosed on a full stomach and a lower maximum peak.…
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Mimicry: The idol of T3-T4 combo therapy 2004-2014
They say that history is written by the victors. Not always. Sometimes histories are written by advocates for the oppressed and disenfranchised. A common theme on our website is the need to see current practices and thyroid therapy challenges in light of thyroid therapy history. Instead of trusting histories written by scientists, one ought to…
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The foundations of synthetic T3-T4 therapy in the 1990s
A trend in thyroid therapy, sparked by a 1995 rat study, attempted to mimic a narrowly estimated T3:T4 ratio secreted by human thyroid glands. This trend was based on a theory of pharmaceutical mimicry of “the” thyroid gland. Its proponents chose to represent every human being’s thyroid gland by the narrow statistical average secretion ratio…
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Free T3 peaks and valleys in T3 and NDT therapy
Lack of knowledge about Free T3 peaks and valleys contributes to failure and frustration in T3-based therapies, including desiccated thyroid and T3-T4 combination therapy. On patient support groups, I often see conversations that go like this: Another common patient exchange usually goes like this: So many times, I’ve thought to myself, “I really wish all…
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Stop spreading the unscientific myth about the normal T4:T3 ratio!
Sigh. Just sigh. Even some of our best thyroid patient advocates can unknowingly share misinformation about thyroid therapy. Mary Shomon’s thyroid articles on Verywell.com are usually to be trusted. But yesterday I was saddened to see that an article supposedly authored by Mary Shomon was spreading unscientific myths about “normal” thyroid secretion ratios being 13:1…