Free T3 peaks and valleys in T3 and NDT therapy

Lack of knowledge about Free T3 peaks and valleys contributes to failure and frustration in T3-based therapies, including desiccated thyroid and T3-T4 combination therapy. On patient support groups, I often see conversations that go like this: "My FT3 result was over reference range, FT4 low in range, and my TSH was low, so my doctor …

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Caution: Doctors perform T3-ectomies without our consent

We all know a "thyroidectomy" is the surgical removal of a thyroid gland. Nobody removes a vital gland without a patient's informed consent. If your medical system and doctor are ethical, you as a patient have the opportunity to weigh the risks and benefits of the procedure and give signed consent. We need to consider …

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Deiodinase Type 3 plays the T3-blocking role

This is part 2 of a 2-part post (It was long, so I've decided to break it into two parts). Images & principles were shared in yesterday's post: Visualizing thyroid hormone activity in cells: T3 and RT3 in context Here's the corrected & clarified image that I developed based on Bianco et al, 2019's model: …

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Visualizing thyroid hormone activity in cells: T3 and RT3 in context

I've recently been inspired by an visual of thyroid hormone cellular action published by Bianco and colleagues in September, 2019. This visual has taught me a new way of seeing these hormones' pathways of movement and activity in our bodies. I've read Bianco's article quite thoroughly in light of the image, and as a result …

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The basics of thyroid hormone action, transport and conversion

This comprehensive educational post collects the basics of thyroid hormone, transport and conversion. T3 action on nuclear receptors Every organ and tissue in your body must maintain a healthy level of T3 hormone activity to function properly. Bloodstream T3 supply and local T3 action powerfully influences how every organ operates, from our liver to our …

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A Dialogue with Utiger: T3-based thyroid therapy over-suppresses TSH

Robert Utiger, M.D. (1931-2008) is well known in endocrinology as the father of the TSH test. Despite his trust in the TSH test, in his publications he acknowledged that TSH behaved very unnaturally in response to T3 levels in blood while dosing T3 thyroid medication. What Utiger discovered in the 1970s and 1980s about the …

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The impact of thyroid hormone dysfunction on ischemic heart disease, and how T3 therapy may help

Finally! In the past, the overemphasis on hyperthyroidism and thyrotoxicosis and heart diseases has made many doctors think that only excess T3 and T4 is bad for the heart. We finally have an article that focuses on the real cause-effect relationships on the opposite end of the thyroid dysfunction spectrum: HYPOthyroidism. This May 2019 article …

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