A Dialogue with Utiger: T3-based thyroid therapy over-suppresses TSH

Robert Utiger, M.D. (1931-2008) is well known in endocrinology as the father of the TSH test. Despite his trust in the TSH test, in his publications he acknowledged that TSH behaved very unnaturally in response to T3 levels in blood while dosing T3 thyroid medication. What Utiger discovered in the 1970s and 1980s about the …

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The impact of thyroid hormone dysfunction on ischemic heart disease, and how T3 therapy may help

Finally! In the past, the overemphasis on hyperthyroidism and thyrotoxicosis and heart diseases has made many doctors think that only excess T3 and T4 is bad for the heart. We finally have an article that focuses on the real cause-effect relationships on the opposite end of the thyroid dysfunction spectrum: HYPOthyroidism. This May 2019 article …

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T3 is not always converted from T4: De novo T3 synthesis

Choosing Wisely Canada, in its campaign to prevent "unnecessary" Free T3 testing in hypothyroidism, says this at the opening of their justification: "T4 is converted into T3 at the cellular level in virtually all organs." (1) Such a statement makes it seem like T3 hormone only originates from T4 hormone. Admittedly, debate and uncertainty has …

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The blindness of TSH to the most powerful thyroid hormone.

Standard therapy for hypothyroidism today is built on a myth of TSH omniscience. "Thyroid stimulating hormone (TSH) is the most sensitive and specific test for the investigation and management of primary thyroid dysfunction" (1) If TSH is so "sensitive," then why is TSH completely blind to blood levels of the most powerful thyroid hormone, T3, …

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REVIEW: TSH does not enhance T3 levels in age

This 2016 research study discovered that TSH plays a role in enhancing T4-T3 conversion, but TSH is less able to enhance T3 levels after age 40. METHODS: Free T3, free T4, and TSH levels from 527, 564 sera collected from patients aged 1 year or greater were studied. ... 27,940 samples remaining after exclusion were stratified …

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2018 study on T4 and T3 in breast cancer

Published August 2018, a new study of T4 and T3 hormones and obesity in relation to breast cancer risk found that higher levels of T4 hormone conferred greater risk, while higher T3 levels had a protective effect. The article Ortega-Olvera, C., Ulloa-Aguirre, A., Ángeles-Llerenas, A., Mainero-Ratchelous, F. E., González-Acevedo, C. E., Hernández-Blanco, M. de L., …

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HISTORY: Rosalind Pitt-Rivers, the co-discoverer of T3 hormone

The co-discoverers of the T3 hormone (triiodothyronine) in 1952 were Rosalind Pitt-Rivers, MD, PhD (London) and Dr. Jack Gross, MD, PhD (McGill) from Canada.   Rosalind Pitt-Rivers' early life Dr. Jamshed Tata, one of Pitt-Rivers' many co-authors, wrote the Biographical Memoirs of Dr. Pitt-Rivers, in 1994. This work is the main source of this profile. Tata …

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