Visualizing thyroid hormone activity in cells: T3 and RT3 in context

I've recently been inspired by an visual of thyroid hormone cellular action published by Bianco and colleagues in September, 2019. This visual has taught me a new way of seeing these hormones' pathways of movement and activity in our bodies. I've read Bianco's article quite thoroughly in light of the image, and as a result …

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The basics of thyroid hormone action, transport and conversion

This comprehensive educational post collects the basics of thyroid hormone, transport and conversion. T3 action on nuclear receptors Every organ and tissue in your body must maintain a healthy level of T3 hormone activity to function properly. Bloodstream T3 supply and local T3 action powerfully influences how every organ operates, from our liver to our …

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The TSH-T3 disjoint in thyroid therapy

There's a deep lie behind today's TSH-based definition of "euthyroid" status and today's policies of TSH normalization in therapy. The lie is that the loss of the thyroid and the initiation of thyroid hormone dosing has NOT altered and skewed natural TSH-FT3-FT4 hormone relationships. Yes, thyroid disease and therapy DO alter and skew these functional …

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The loss of thyroid clinical knowledge from Werner & Ingbar’s The Thyroid

Decades ago, a lot more doctors knew how thyroid hormone levels influenced all organs and tissues’ health. It wasn’t all about the influence of thyroid hormones on the TSH. It was more about the influence of truly adequate thyroid hormone levels on real health outcomes. A lot more doctors learned and understood that if thyroid …

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The impact of thyroid hormone dysfunction on ischemic heart disease, and how T3 therapy may help

Finally! In the past, the overemphasis on hyperthyroidism and thyrotoxicosis and heart diseases has made many doctors think that only excess T3 and T4 is bad for the heart. We finally have an article that focuses on the real cause-effect relationships on the opposite end of the thyroid dysfunction spectrum: HYPOthyroidism. This May 2019 article …

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Type 2 Diabetes and Hyper- versus Hypothyroidism

Surprise surprise. Having less thyroid hormone makes you more susceptible to Type 2 Diabetes. How does it work? Quote from Dr. Chaker, lead author: “Thyroid hormone is also directly involved in the control of insulin secretion and glucose homeostasis. Hypothyroidism is associated with decreased insulin sensitivity and glucose tolerance and treatment of hypothyroidism has shown …

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A Thyroid Patients Manifesto

Manifesto: "a written statement declaring publicly the intentions, motives, or views of its issuer" (Merriam-Webster) I humbly offer the following manifesto for us as thyroid patients. WE, as citizens maintained by thyroid hormone therapy, declare our equal rights to health and well being. We have the right to agency and choice within our thyroid therapy. …

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