This comprehensive educational post collects the basics of thyroid hormone, transport and conversion. T3 action on nuclear receptors Every organ and tissue in your body must maintain a healthy level of T3 hormone activity to function properly. Bloodstream T3 supply and local T3 action powerfully influences how every organ operates, from our liver to our … Continue reading The basics of thyroid hormone action, transport and conversion
Robert Utiger, M.D. (1931-2008) is well known in endocrinology as the father of the TSH test. Despite his trust in the TSH test, in his publications he acknowledged that TSH behaved very unnaturally in response to T3 levels in blood while dosing T3 thyroid medication. What Utiger discovered in the 1970s and 1980s about the … Continue reading A Dialogue with Utiger: T3-based thyroid therapy over-suppresses TSH
Finally! In the past, the overemphasis on hyperthyroidism and thyrotoxicosis and heart diseases has made many doctors think that only excess T3 and T4 is bad for the heart. We finally have an article that focuses on the real cause-effect relationships on the opposite end of the thyroid dysfunction spectrum: HYPOthyroidism. This May 2019 article … Continue reading The impact of thyroid hormone dysfunction on ischemic heart disease, and how T3 therapy may help
Choosing Wisely Canada, in its campaign to prevent "unnecessary" Free T3 testing in hypothyroidism, says this at the opening of their justification: "T4 is converted into T3 at the cellular level in virtually all organs." (1) Such a statement makes it seem like T3 hormone only originates from T4 hormone. Admittedly, debate and uncertainty has … Continue reading T3 is not always converted from T4: De novo T3 synthesis
Standard therapy for hypothyroidism today is built on a myth of TSH omniscience. "Thyroid stimulating hormone (TSH) is the most sensitive and specific test for the investigation and management of primary thyroid dysfunction" (1) If TSH is so "sensitive," then why is TSH completely blind to blood levels of the most powerful thyroid hormone, T3, … Continue reading The blindness of TSH to the most powerful thyroid hormone.