The loss of thyroid clinical knowledge from Werner & Ingbar’s The Thyroid

Decades ago, a lot more doctors knew how thyroid hormone levels influenced all organs and tissues’ health. It wasn’t all about the influence of thyroid hormones on the TSH. It was more about the influence of truly adequate thyroid hormone levels on real health outcomes. A lot more doctors learned and understood that if thyroid …

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L-T3 pharmaceutical equivalency, Part 2: New thyroid science

What does NEW thyroid science have to say on the topic of thyroid pharmaceutical equivalency? How many micrograms of L-T3 Liothyronine (i.e. Cytomel) are equivalent to L-T4 Levothyroxine (i.e. Synthroid)? Thyroid hormone pharmaceutical monographs currently provide very rigid and low-ratio equivalency statements: ERFA Canada says "Desiccated thyroid 60 mg is usually considered equivalent to ... …

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No, 25 mcg of L-T3 Liothyronine isn’t equivalent to 100 mcg L-T4

In thyroid therapy, how many micrograms of Cytomel (T3) are equivalent to how many micrograms of Synthroid (T4)? Equivalency statements in the product monographs for Pfizer Canada's Cytomel and for ERFA Canada's "Thyroid" (NDT brand) claim that a 25 mcg dose of Liothyronine sodium (L-T3) is "considered equivalent" to 100 mcg / μg (0.1 mg) …

Continue reading No, 25 mcg of L-T3 Liothyronine isn’t equivalent to 100 mcg L-T4

A Dialogue with Utiger: T3-based thyroid therapy over-suppresses TSH

Robert Utiger, M.D. (1931-2008) is well known in endocrinology as the father of the TSH test. Despite his trust in the TSH test, in his publications he acknowledged that TSH behaved very unnaturally in response to T3 levels in blood while dosing T3 thyroid medication. What Utiger discovered in the 1970s and 1980s about the …

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Flexible-Ratio T3, T4, and NDT Combination Thyroid Therapy

Here I bring thyroid science into a discussion of effectively adapting and managing the most flexible form of thyroid therapy, T4-T3 combination therapy. This is a model capable of adapting to an individual's unique thyroid disability and response to thyroid medication. Finding an individual's optimal combination therapy is medically necessary when T4 monotherapy fails due …

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The mini-T3-mono-combination therapy model vs NDT and others

I'd like to talk about contemporary researchers' rigid and limited approach to combination therapy. This is the model whose many limitations I point out with the ridiculously long label "mini-T3-mono-combination" therapy. I'll go over some of the history behind this model, the source of the rigid ratios that we learned about in our series on …

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Thyroid therapies: What my life is like in the T3-monotherapy wheelchair

Here, I'll use my own personal example to discuss a few dimensions of T3 monotherapy, which I envision as a "wheelchair." I'm drawing on the fictional analogy I developed in an earlier post, where I imagined thyroid disease like crippling foot disease. The therapy of 100% T4 can be seen like a walking stick or …

Continue reading Thyroid therapies: What my life is like in the T3-monotherapy wheelchair