T3 hormone
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How do we get enough T3 into thyroid hormone receptors?
In thyroid disease and therapy, even when TSH is normalized, we can still be genuinely hypothyroid if we do not have enough T3 getting into our thyroid hormone receptors in cells throughout the body. Most people know there’s two ways we get T3 into our cells’ nuclei: From circulating Free T3, and From circulating Free…
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Free T3 peaks and valleys in T3 and NDT therapy
Lack of knowledge about Free T3 peaks and valleys contributes to failure and frustration in T3-based therapies, including desiccated thyroid and T3-T4 combination therapy. On patient support groups, I often see conversations that go like this: Another common patient exchange usually goes like this: So many times, I’ve thought to myself, “I really wish all…
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Caution: Doctors perform T3-ectomies without our consent
We all know a “thyroidectomy” is the surgical removal of a thyroid gland. Nobody removes a vital gland without a patient’s informed consent. If your medical system and doctor are ethical, you as a patient have the opportunity to weigh the risks and benefits of the procedure and give signed consent. We need to consider…
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Deiodinase Type 3, not RT3, plays the T3-blocking role
A lot of internet myths and misinformation surrounds Reverse T3 (RT3). Well-meaning people have attributed to the hormone a “T3-blocking” function. However, the enzyme deiodinase type 3 (D3) (NOT Vitamin D3, which is very different) is the main blocker of T3 hormone. Deiodinase type 3 (D3), regulated by the DIO3 gene, is the enzyme that…
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Visualizing thyroid hormone activity in cells: T3 and RT3 in context
I’ve recently been inspired by an visual of thyroid hormone cellular action published by Bianco and colleagues in September, 2019. This visual has taught me a new way of seeing these hormones’ pathways of movement and activity in our bodies. I’ve read Bianco’s article quite thoroughly in light of the image, and as a result…