There's a deep lie behind today's TSH-based definition of "euthyroid" status and today's policies of TSH normalization in therapy. The lie is that the loss of the thyroid and the initiation of thyroid hormone dosing has NOT altered and skewed natural TSH-FT3-FT4 hormone relationships. Yes, thyroid disease and therapy DO alter and skew these functional … Continue reading The TSH-T3 disjoint in thyroid therapy
Table 17.1 in Braverman & Cooper's 2013 chapter in Werner & Ingbar's The Thyroid textbook, 10th edition, lists many causes of thyrotoxicosis. One of the interesting causes of thyrotoxicosis, rarely mentioned in public discourse, is "Circulating hCG or Mutant TSHR [TSH receptor] hypersensitive to hCG." What is hCG? "Human chorionic gonadotropin" is a hormone produced … Continue reading Pregnancy thyrotoxicosis vs just a low TSH due to hCG hormone
This post takes a closer look at the "ultrashort feedback loop," the biological mechanism by which the TSHR stimulating antibody (TSAb) can oversuppress or inflate TSH in any autoimmune hypothyroid patient. The antibody's effect alters the normal TSH-FT4 relationship. It may look like the patient has another thyroid condition: It may mimic "Resistance to thyroid … Continue reading How TSH ultrashort feedback works, and antibody interference
Many substances and health factors can, independently of thyroid hormones, lower TSH secretion significantly. These factors are not listed in Braverman & Cooper's chapter on thyrotoxicosis in Werner & Ingbar's The Thyroid textbook, 10th edition 2013, because their chapter avoids defining the syndrome by a low TSH. Nevertheless, these TSH-lowering factors should always be mentioned … Continue reading Thyrotoxicosis? Many factors can lower TSH
This post walks through the process of using the SPINA-Thyr to interpret thyroid lab test results. OVERVIEW SPINA-Thyr is a free diagnostic application developed by research endocrinologists who use it in peer-reviewed medical research. SPINA-Thyr has been in development since the late 1990s under the leadership of Dr. Johannes Dietrich, Specialist in internal medicine, endocrinology and … Continue reading Analyze thyroid lab results using SPINA-Thyr
