The loss of thyroid clinical knowledge from Werner & Ingbar’s The Thyroid

Decades ago, a lot more doctors knew how thyroid hormone levels influenced all organs and tissues’ health. It wasn’t all about the influence of thyroid hormones on the TSH. It was more about the influence of truly adequate thyroid hormone levels on real health outcomes. A lot more doctors learned and understood that if thyroid …

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Simpson’s paradox: Hoermann et al explain why T4-T3 therapy trials are faulty

Why have clinical trials of T3-T4 combination therapy failed to show significant benefit? Hoermann et al explain that the trials and the meta-analyses exhibit a fundamental problem with research methodology and a fundamental misunderstanding of thyroid hormone relationships that results in statistical errors. SOURCE Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J. …

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2017 study of T2 hormones, blood glucose and other metabolic markers

Do you know about the effects of the two kinds of T2 thyroid hormone that your body produces? A significant 2017 mouse study examined treatment with T3 as well as two types of T2 hormone. One type of T2 is produced by removing iodine from the outer ring of the T3 molecule. The other type …

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Fear of Low TSH causing osteoporosis

Image based on Figure 4 in this source: Gogakos, A. I., Duncan Bassett, J. H., & Williams, G. R. (2010). Thyroid and bone. Archives of Biochemistry and Biophysics, 503(1), 129–136. https://doi.org/10.1016/j.abb.2010.06.021 Dear Doctors, You may experience this scenario with some of your thyroid patients. Your patient's TSH is near the bottom of reference range, but …

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When is Low TSH not hyperthyroidism?

Q: When is a low TSH not hyperthyroidism? The answer is huge -- in central hypothyroidism, in low T3 syndrome, in the first trimester of pregnancy... AND in cases where thyroid therapy achieves euthyroid status without causing tissue thyrotoxicosis. In many posts on this blog, we've detailed the reasons why TSH is a poor indicator …

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REVIEW: DIO1 gene affects T3:T4 ratio

Panicker et al, 2008 Click title to read it online: A Common Variation in Deiodinase 1 Gene DIO1 Is Associated with the Relative Levels of Free Thyroxine and Triiodothyronine Background "D1 is found in liver, kidney, thyroid, and pituitary" and as blood flows through these organs, D1 converts T4 into T3, increasing levels of Free T3 …

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