This article is for people interested in getting an overview of the influence of thyroid hormones on bone health at the molecular level. It outlines the way bone transports, metabolizes, and uses thyroid hormones T3 and T4. It also raises theoretical implications for people with low T3 during TSH-suppressive T4 monotherapy. Here I draw mainly … Continue reading The science of thyroid hormone and bone metabolism
Category: Bones
As of 2019, still no proof that low TSH causes harm to bones
Many research studies have shown a strong association between low TSH and low bone mineral density or osteoporosis. As a result, many guidelines strongly caution against the risk associated with low TSH. Some doctors and thyroid patients have jumped to the conclusion that a low TSH “causes” osteoporosis. Some even believe a low TSH must … Continue reading As of 2019, still no proof that low TSH causes harm to bones
Overlooked: Hypothyroidism causes osteosclerosis
We should all know that thyrotoxicosis in bone, caused by too much T3 binding to receptors in cells, leads to osteoporosis. (Bassett et al, 2007; Gogakos et al, 2010) Hypothyroidism in bone, characterized by low T3 in bone, is not good for bone, either. (Bassett et al, 2008) Hypothyroidism results in a different bone disorder … Continue reading Overlooked: Hypothyroidism causes osteosclerosis
Fear of Low TSH causing osteoporosis
Image based on Figure 4 in this source: Gogakos, A. I., Duncan Bassett, J. H., & Williams, G. R. (2010). Thyroid and bone. Archives of Biochemistry and Biophysics, 503(1), 129–136. https://doi.org/10.1016/j.abb.2010.06.021 Dear Doctors, You may experience this scenario with some of your thyroid patients. Your patient's TSH is near the bottom of reference range, but … Continue reading Fear of Low TSH causing osteoporosis