This summary blog post will take you through a visual journey as you follow thyroid hormones through bloodstream, transporters, cells, and receptors. This infographic is not like most others you'll see that portray a gland-centric view of the HPT axis. Instead, I take a hormone-centric view. The thyroid hormones themselves are the heroes of their … Continue reading Infographic: Thyroid hormone journey
No, this is not just an article for thyroid science buffs. Anyone who claims to understand thyroid hormone metabolism should become comfortable using the word "deiodinase." It's just as important a word for thyroid disease as "insulin" is for diabetes. Three enzymes convert thyroid hormones throughout our bodies: Deiodinase type 1, Deiodinase type 2, and … Continue reading Tissue RNA expression of DIO1, DIO2, and DIO3
This post follows up on several recent posts on the topic of Reverse T3 (RT3) and our thyroid hormone conversion enzymes, the three deiodinases. Here I'm providing some practical tips about Reverse T3 testing, test interpretation, and where we should be focusing our attention. In these posts, I aim to improve thyroid therapy by debunking … Continue reading Principles and Practical tips for Reverse T3, FT3, FT4
[Post updated May 2, 2021] Many thyroid patients have acquired concerns about Reverse T3 (RT3) by reading Kent Holtorf's web pages. Likely even more have learned by reading Reverse T3 information on the Stop the Thyroid Madness (STTM) thyroid patients' website, which has been influenced by Holtorf, whom they cite. On the positive side, both … Continue reading RT3 inhibits T4-T3 conversion. How worried should we be?
A lot of internet myths and misinformation surrounds Reverse T3 (RT3). Well-meaning people have attributed to the hormone a “T3-blocking” function. However, the enzyme deiodinase type 3 (D3) (NOT Vitamin D3, which is very different) is the main blocker of T3 hormone. Deiodinase type 3 (D3), regulated by the DIO3 gene, is the enzyme that … Continue reading Deiodinase Type 3, not RT3, plays the T3-blocking role