T4-monotherapy
-
Thyroid patients suffer from T4 monotherapy
The standard T4 monotherapy results in unnatural distortions in T3:T4 ratios that can lead to chronic T3 concentrations below the healthy mean when TSH is normalized. But health care systems in Canada do not care how much FT3 you lose compared to other Canadian citizens when you are on T4 monotherapy. They don’t want to…
-
2018 study shows T3 in upper half of reference range relieves hypothyroid symptoms
This Sept. 2018 research article proved that thyroid patients’ continued hypothyroid symptoms are connected to Free T3 levels.(1) Symptom relief for thyroid patients on the standard T4 monotherapy is found “in the upper half of the FT3 reference range.” Symptoms had a limited and paradoxical relationship with TSH, and absolutely no relationship to a patient’s…
-
Ubiquitination: The glass ceiling of T4 monotherapy
UBIQUITINATION: This is the “Glass ceiling” of T4 monotherapy — in some patients, there is a biological limit on how much T3 they can get out of treatment with T4 thyroid hormone alone (Synthroid, levothyroxine). Scientists recently explained how D2’s gene (DIO3) is inactivated by rising levels of T4: “Although DIO2 expression is only weakly…
-
Thyroid hormone economics 101: Less FT3 per unit of TSH
Despite a normal TSH, some thyroid patients will fall far below their healthy set point for Free T3, the active thyroid hormone. TSH behaves differently in thyroid patients. TSH cannot indicate T3 sufficiency in thyroid therapy. Source of graph: Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J. W. (2016). Relational Stability in…
-
REVIEW: Ineffectiveness of L-T4 monotherapy in subclinical hypothyroidism
A new study published October 2018 has reviewed prior research on levothyroxine monotherapy in cases of “subclinical hypothyroidism” and has found it to be ineffective in improving quality of life and thyroid-related symptoms in patients. Studies like these could logically be used to launch a staunch critique against the presumed effectiveness of normalizing TSH via…