thyroidpatientsca
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Ubiquitination: The glass ceiling of T4 monotherapy
UBIQUITINATION: This is the “Glass ceiling” of T4 monotherapy — in some patients, there is a biological limit on how much T3 they can get out of treatment with T4 thyroid hormone alone (Synthroid, levothyroxine). Scientists recently explained how D2’s gene (DIO3) is inactivated by rising levels of T4: “Although DIO2 expression is only weakly…
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Our response to Choosing Wisely’s harmful Table 2
Choosing Wisely Canada, together with the Canadian Society for Endocrinology and Metabolism, have collaborated on a harmful toolkit to reduce Free T3 and Free T4 hormone testing in order to save money. As you can see in their Table 2 from page 9 of their toolkit, they want to prevent T3 and T4 testing in…
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BIBLIO: Atrophic Thyroiditis
We have compiled a bibliography on Atrophic Thyroiditis and the TSHR antibody that is continually under development. 127 items exist in the bibliography as of December 2018 Screenshot The database is in a Google Spreadsheet. Click this link to access : https://docs.google.com/spreadsheets/d/1MlwMCGUnEF_ptUE9S9znMnN5oNkuAqA2fUNxvD2zrRw/edit?usp=sharing
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Simpson’s paradox: Hoermann et al explain why T4-T3 therapy trials are faulty
Why have clinical trials of T3-T4 combination therapy failed to show significant benefit? Hoermann et al explain that the trials and the meta-analyses exhibit a fundamental problem with research methodology and a fundamental misunderstanding of thyroid hormone relationships that results in statistical errors. SOURCE Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J.…
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The THIRD type of autoimmune thyroid disease: Atrophic Thyroiditis
Do you know about the THIRD type of autoimmune thyroid disease? Atrophic thyroiditis may coexist with Hashimoto’s and can occur in people with Graves’ disease. Atrophic Thyroiditis is an extreme form of primary hypothyroidism in which the thyroid gland is severely atrophied (shrunken, shrivelled) by antibody attack. In some estimates, approximately 10% of Hashimoto’s patients…