Healthy thyroid axis
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Question Pilo’s Study: Thyroid Hormone Reductionism
Many aspects of biology are incredibly complex. People love simplicity. It’s necessary for a model to reduce a system down to its basic principles and proportions. Pilo’s research study published in 1990 is now cited as the definitive proof of where human beings’ T3 thyroid hormone supply comes from. Pilo’s paper is what many people…
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Question Pilo’s study: The wide range of thyroid hormone adaptation
Doctors today are taught that “the” thyroid secretes T4 and T3 at a ratio of 14:1, or 15:1, and “the” human body converts 80% of its T3 supply from T4. These ratios are now taught and passed on as if they are static, immutable laws of nature, like the law of gravity. However, studies of complex…
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Question Pilo’s study: Iodine dosing biases T4:T3 secretion
This post continues my series that examines two ratios T4:T3 thyroid hormone secreted by “the” thyroid gland. The single origin of both these ratios is an article by Pilo et al published in 1990. A simple summary: In Pilo’s’ study, the huge doses of iodine these 14 people were given every day during the…
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The two T4-T3 ratios that confine thyroid therapy
Here are the two most pervasive, limiting, and potentially harmful presumptions about T3:T4 hormone ratios in thyroid science today. Ratio #1: There is a perfect physiological T4:T3 ratio secreted from the healthy human thyroid gland, and it is approximately 15:1. (Various ratios are cited, most often from 13:1 to 16:1) Ratio #2: In the…
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REVIEW: TSH does not enhance T3 levels in age
This 2016 research study discovered that TSH plays a role in enhancing T4-T3 conversion, but TSH is less able to enhance T3 levels after age 40. METHODS: Free T3, free T4, and TSH levels from 527, 564 sera collected from patients aged 1 year or greater were studied. … 27,940 samples remaining after exclusion were stratified…