HPT axis
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Summary: T3 secretion and T4-T3 conversion
My article published May 4, 2020, “Thyroid T3 secretion compensates for T4-T3 conversion” has received very strong positive feedback. People are saying that it’s a ground-breaking, game-changing article on the HPT axis in health versus thyroid disease, and that it ought to be essential reading. In a nutshell, my long article re-analyzes the published data…
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Thyroid T3 secretion compensates for peripheral T4-T3 conversion
In health, what happens when your tissues don’t convert enough T4 into T3 hormone? Your healthy thyroid secretes more T3. The healthy thyroid gland’s synthesis of T3 de novo (from raw materials of iodine and tyrosine) under the stimulation of a healthy TSH can maintain your circulating T3 supply. This prevent tissues from becoming hypothyroid…
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7 ways to raise TSH without reducing thyroid dose
You’ve just come to your doctor for your annual check-up. Either you feel fine and you want to get a renewal of your current thyroid prescription, or you feel rather hypothyroid and you’re hoping to get an increased dose. But your doctor has been trained to say this: “Your TSH is below reference (or too…
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Screening for central hypothyroidism during thyroid therapy
As I’ve outlined in a previous post, central hypothyroidism (CeH) is a failure or compromise in the hypothalamus and/or pituitary gland that causes defective TSH or inappropriately low TSH secretion. There, I echoed the complaints of world-leading experts in the field, Beck-Peccoz and Persani, who point out why it is so difficult to diagnose central…
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Why is central hypothyroidism so difficult to diagnose?
Every thyroid patient and doctor should become more informed about the challenges of diagnosing central hypothyroidism. Did you know that people can even have elevated TSH levels in central hypothyroidism? Wow, really? Yes, the research says so. A graph of research results reveals it clearly, too. Not only that, but here’s another shocker. As of…