Scientific research analysis
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Ataoglu: Low T3 in critical illness is deadly, and adding high T4 is worse.
In 2018, Ataoglu and colleagues confirmed and expanded our knowledge of “Low T3 syndrome.” Despite a normalized TSH, a Low T3 is deadly not only in acute, critical illness, but in “chronic disease.” To be specific, Low T3 is more deadly in some health conditions than others. What should be really shocking to many is…
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In Winter, everyone gains T3 except thyroidless patients on LT4 therapy
In this article I examine the research results depicted in the graph above. Gullo and team’s 2017 article reported research on 11,806 healthy controls and 3,934 thyroidless people treated with L-T4 monotherapy in Sicily, Italy. They discovered that the thyroid-disabled people lost a “significant” amount of Free T4 and Free T3 hormone in winter, on…
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The science of thyroid hormone and bone metabolism
This article is for people interested in getting an overview of the influence of thyroid hormones on bone health at the molecular level. It outlines the way bone transports, metabolizes, and uses thyroid hormones T3 and T4. It also raises theoretical implications for people with low T3 during TSH-suppressive T4 monotherapy. Here I draw mainly…
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As of 2019, still no proof that low TSH causes harm to bones
Many research studies have shown a strong association between low TSH and low bone mineral density or osteoporosis. As a result, many guidelines strongly caution against the risk associated with low TSH. Some doctors and thyroid patients have jumped to the conclusion that a low TSH “causes” osteoporosis. Some even believe a low TSH must…
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2014 ATA therapy guidelines: 5. Research
This post continues my series of paraphrases of Jonklaas et al’s 2014 guidelines that I left unfinished weeks ago. Posts in this series: 2014 ATA Thyroid therapy guidelines: 1. Levothyroxine 2014 ATA Thyroid therapy guidelines: 2. Ethics 2014 ATA Therapy guidelines: 3. Desiccated thyroid 2014 ATA Therapy guidelines: 4. Using Synthetic T3 2014 ATA therapy…