Research Reviews
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2018 study shows T3 in upper half of reference range relieves hypothyroid symptoms
This Sept. 2018 research article proved that thyroid patients’ continued hypothyroid symptoms are connected to Free T3 levels.(1) Symptom relief for thyroid patients on the standard T4 monotherapy is found “in the upper half of the FT3 reference range.” Symptoms had a limited and paradoxical relationship with TSH, and absolutely no relationship to a patient’s…
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Simpson’s paradox: Hoermann et al explain why T4-T3 therapy trials are faulty
Why have clinical trials of T3-T4 combination therapy failed to show significant benefit? Hoermann et al explain that the trials and the meta-analyses exhibit a fundamental problem with research methodology and a fundamental misunderstanding of thyroid hormone relationships that results in statistical errors. SOURCE Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J.…
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Trials of T3, desiccated thyroid and thyroxine in 1958
Here’s my review of this treasure, an article about T3 therapy from the scientific literature in the 1950s… TITLE: “TRIIODOTHYRONINE—Clinical Effects in Patients with Suboptimal Response to Other Thyroid Preparations” — LINK: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1512399/ In this article, “Thirty patients with evidence of hypometabolism or a clinically related condition were given triiodothyronine after suboptimal response to thyroxin or…
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REVIEW: Ineffectiveness of L-T4 monotherapy in subclinical hypothyroidism
A new study published October 2018 has reviewed prior research on levothyroxine monotherapy in cases of “subclinical hypothyroidism” and has found it to be ineffective in improving quality of life and thyroid-related symptoms in patients. Studies like these could logically be used to launch a staunch critique against the presumed effectiveness of normalizing TSH via…
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REVIEW: TSH does not enhance T3 levels in age
This 2016 research study discovered that TSH plays a role in enhancing T4-T3 conversion, but TSH is less able to enhance T3 levels after age 40. METHODS: Free T3, free T4, and TSH levels from 527, 564 sera collected from patients aged 1 year or greater were studied. … 27,940 samples remaining after exclusion were stratified…