Thyrotoxicosis? Many factors can lower TSH

Many substances and health factors can, independently of thyroid hormones, lower TSH secretion significantly. These factors are not listed in Braverman & Cooper’s chapter on thyrotoxicosis in Werner & Ingbar’s The Thyroid textbook, 10th edition 2013, because their chapter avoids defining the syndrome by a low TSH. Nevertheless, these TSH-lowering factors should always be mentioned along with “thyrotoxicosis” in the context of today’s TSH-worship. Whenever doctors see low TSH lab results with normal thyroid hormones, they may presume it’s subclinical thyrotoxicosis and that they must do something about it. Essentially, these are temporary and variable factors that induce “acquired central …

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Thyrotoxicosis: Symptoms and signs

Much confusion exists about the value of symptoms and signs in the diagnosis of thyrotoxicosis. The most common view is to dismiss symptoms entirely because each, considered separately, is “nonspecific” to thyrotoxicosis. However, there is no such thing as a “thyroid-specific” symptom because thyroid hormones have their effects in every organ and system of the body.  What’s do the experts recommend? Look for several symptoms manifesting at once. Braverman & Cooper’s 2013 chapter in Werner & Ingbar’s The Thyroid, 10th edition, says “it is usually the combination of several that suggests the possibility of the disorder.” Their chapter divides a list into …

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References for Thyrotoxicosis vs. Low TSH series

Posts in this series July 2019 Thyrotoxicosis? Many factors can lower TSH Thyrotoxicosis: Symptoms and signs Thyrotoxicosis vs. Low TSH Thyrotoxicosis can occur with high or normal TSH? TSH “can be very misleading” during thyroid therapy, say researchers How TSH ultrashort feedback works, and antibody interference Pregnancy thyrotoxicosis vs just a low TSH due to HCG hormone REFERENCES Anderson, J. L., Jacobs, V., May, H. T., Bair, T. L., Lappé, D. L., Muhlestein, J. B., … Bunch, T. J. (2018). Abstract 11290: Free Thyroxine (fT4) Within the Reference (‘Normal’) Range Predicts Risk of Atrial Fibrillation. Circulation, 138(Suppl_1), A11290–A11290. https://doi.org/10.1161/circ.138.suppl_1.11290 Bargi-Souza, …

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