Research Reviews
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The TSH-T3 disjoint in thyroid therapy
There’s a deep lie behind today’s TSH-based definition of “euthyroid” status and today’s policies of TSH normalization in therapy. The lie is that the loss of the thyroid and the initiation of thyroid hormone dosing has NOT altered and skewed natural TSH-FT3-FT4 hormone relationships. Yes, thyroid disease and therapy DO alter and skew these functional…
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Stop spreading the unscientific myth about the normal T4:T3 ratio!
Sigh. Just sigh. Even some of our best thyroid patient advocates can unknowingly share misinformation about thyroid therapy. Mary Shomon’s thyroid articles on Verywell.com are usually to be trusted. But yesterday I was saddened to see that an article supposedly authored by Mary Shomon was spreading unscientific myths about “normal” thyroid secretion ratios being 13:1…
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Low T3 syndrome in thyroid therapy: THREE studies
In contrast with a long list of over 70 medical research articles on low T3 syndrome that excluded thyroid patients, I have only found three (3) studies so far that included patients being treated for hypothyroidism. I’ll reveal their treasures and disappointments in reverse date order: Somppi, 2017 Tevaarwerk, 2014 Wadwekar, 2004 Here’s how many…
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Ataoglu: Low T3 in critical illness is deadly, and adding high T4 is worse.
In 2018, Ataoglu and colleagues confirmed and expanded our knowledge of “Low T3 syndrome.” Despite a normalized TSH, a Low T3 is deadly not only in acute, critical illness, but in “chronic disease.” To be specific, Low T3 is more deadly in some health conditions than others. What should be really shocking to many is…
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In Winter, everyone gains T3 except thyroidless patients on LT4 therapy
In this article I examine the research results depicted in the graph above. Gullo and team’s 2017 article reported research on 11,806 healthy controls and 3,934 thyroidless people treated with L-T4 monotherapy in Sicily, Italy. They discovered that the thyroid-disabled people lost a “significant” amount of Free T4 and Free T3 hormone in winter, on…