Thyroid hormone effects
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The loss of thyroid clinical knowledge from Werner & Ingbar’s The Thyroid
Decades ago, a lot more doctors knew how thyroid hormone levels influenced all organs and tissues’ health. It wasn’t all about the influence of thyroid hormones on the TSH. It was more about the influence of truly adequate thyroid hormone levels on real health outcomes. A lot more doctors learned and understood that if thyroid…
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The science of thyroid hormone and bone metabolism
This article is for people interested in getting an overview of the influence of thyroid hormones on bone health at the molecular level. It outlines the way bone transports, metabolizes, and uses thyroid hormones T3 and T4. It also raises theoretical implications for people with low T3 during TSH-suppressive T4 monotherapy. Here I draw mainly…
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Overlooked: Hypothyroidism causes osteosclerosis
We should all know that thyrotoxicosis in bone, caused by too much T3 binding to receptors in cells, leads to osteoporosis. (Bassett et al, 2007; Gogakos et al, 2010) Hypothyroidism in bone, characterized by low T3 in bone, is not good for bone, either. (Bassett et al, 2008) Hypothyroidism results in a different bone disorder…
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Pregnancy thyrotoxicosis vs just a low TSH due to hCG hormone
Table 17.1 in Braverman & Cooper’s 2013 chapter in Werner & Ingbar’s The Thyroid textbook, 10th edition, lists many causes of thyrotoxicosis. One of the interesting causes of thyrotoxicosis, rarely mentioned in public discourse, is “Circulating hCG or Mutant TSHR [TSH receptor] hypersensitive to hCG.” What is hCG? “Human chorionic gonadotropin” is a hormone produced…
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Thyrotoxicosis can occur with high or normal TSH?
Table 17.1 in Braverman & Cooper’s 2013 chapter in Werner & Ingbar’s The Thyroid textbook, 10th edition, lists many causes of thyrotoxicosis. The only time the TSH _hormone_ is listed as a cause of thyrotoxicosis is in the case of “Inappropriate TSH hypersecretion.” If thyrotoxicosis can occur when TSH is inappropriately _high_ or non-suppressed in…